Sex Differences in Exercise-Induced Hypoalgesia Following Aerobic Exercise Using a Lower-Limb Cycle Ergometer: A Quasi-Experimental Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Pressure Pain Threshold at Quadriceps
研究概览
简要总结
Exercise-induced hypoalgesia (EIH) refers to the reduction in pain sensitivity following acute exercise. Although aerobic exercise has been shown to induce hypoalgesia in healthy individuals, it remains unclear whether the magnitude of this response differs between men and women.
This quasi-experimental study aims to evaluate sex differences in pressure pain thresholds following a standardized aerobic exercise protocol using a lower-limb cycle ergometer. Pressure pain thresholds will be assessed before exercise, immediately after exercise, and 30 minutes after exercise in healthy adults aged 18 to 65 years.
The findings of this study may contribute to improving individualized exercise prescription strategies based on sex differences in pain modulation.
详细描述
Exercise-induced hypoalgesia (EIH) is characterized by a transient reduction in pain sensitivity following acute physical exercise, measurable through pressure pain thresholds (PPTs). Aerobic exercise has been consistently shown to increase PPTs in healthy individuals through activation of endogenous pain inhibitory mechanisms, including opioid and non-opioid pathways.
However, the influence of biological sex on EIH remains unclear, and understanding potential differences between men and women could have important implications for exercise prescription in clinical and healthy populations.
This quasi-experimental study will include healthy male and female participants aged 18-65 years. Participants will undergo a single session of aerobic exercise on a lower-limb cycle ergometer at 70% heart rate reserve for 30 minutes.
Pressure pain thresholds will be assessed using a validated digital pressure algometer at:
- Quadriceps muscle (local site)
- Lateral epicondyle region (remote site)
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male and female adults
- •Age between 18 and 65 years
- •Able to perform moderate-to-vigorous aerobic exercise
- •Able to understand study procedures
- •Cleared for exercise participation using the Physical Activity Readiness Questionnaire (PAR-Q).
排除标准
- •Cardiovascular, respiratory, neurological, or metabolic diseases contraindicating exercise
- •Current musculoskeletal pain or injury
- •Analgesic medication use within 24 hours prior to testing
- •Vigorous exercise within 24 hours prior to testing
- •Any contraindication to aerobic exercise
研究组 & 干预措施
Male participants
Participants will perform a 30-minute aerobic exercise protocol on a lower-limb cycle ergometer at 70% heart rate reserve, including warm-up and cool-down periods.
干预措施: Aerobic exercise using cycle ergometer (Behavioral)
Female participants
Aerobic exercise using lower-limb cycle ergometer. Participants will perform the same aerobic exercise protocol.
干预措施: Aerobic exercise using cycle ergometer (Behavioral)
结局指标
主要结局
Pressure Pain Threshold at Quadriceps
时间窗: Pre-exercise, immediately post-exercise, and 30 minutes post-exercise
Pressure pain threshold measured using a digital pressure algometer at the quadriceps muscle.
次要结局
- Pressure Pain Threshold at Lateral Epicondyle(Pre-exercise, immediately post-exercise, and 30 minutes post-exercise)
研究者
Álvaro Reina Varona
Principal Investigator
Centro Universitario La Salle