Effect of amitriptyline in functional heartburn - amitriptyline and heartburn

Academisch Medisch Centrum0 个研究点目标入组 25 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•* Minimum age: 18 years
•* Documented functional heartburn
•* Negative esophagogastroduodenoscopy and no history of reflux esophagitis
•* Negative 24h pH/impedance recording (physiological acid exposure time) and negative symptom association probability

•* Surgery of the esophagus
•* Motility disorders of the GI tract leading to delayed gastric emptying or altered intestinal motility
•* Use of any medication with a potential effect on upper gastrointestinal motility and/or sensitivity that can not be stopped for the duration of the study. If this medication can be stopped, it should be discontinued for at least 2 weeks before the start of the study.
•* Severe and clinically unstable concomitant disease (e.g. liver, cardiovascular or lung disease, neurological or psychiatric disorders, cancer or AIDS and other endocrine disorders)
•* Pregnancy or lactation. A pregnancy test will be carried out prior to inclusion in the study. Female patients who are premenopausal and have a negative pregnancy test should be on an anticonceptive.;* Medication-related
•* Contra-indications for amitriptyline use: epilepsy, organic central nervous system disorders, prostate hypertrophy, pyloric stenosis, cardiovascular disease, hyperthyroidism, liver- and kidney function impairment.
•* Interaction can occur with barbiturates, carbamazepine, ketoconazol and ritonavir . Concommitant use of MAO-inhibitors is contra-indicated.
•* Hypersensitivity to the active substance or to any of the excipients.

发起方