Evaluation of Richmond Agitation Sedation Scale According to Alveolar Concentration of Sevoflurane During a Sedation With Sevoflurane in ICU Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Description of the RASS score
研究概览
简要总结
Describe the Richmond Agitation Sedation Scale (RASS) values corresponding to the values of Minimum alveolar concentration of sevoflurane during sedation of patients in ICU
详细描述
Prospective clinical study in ICU with sedated ventilated patients with sevoflurane using the Mirus® system. Pharmacological study of the concentration-effect relationship by administration at increasing and decreasing concentrations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Requiring sedation by sevoflurane in ICU
- •Adult patients
- •Patients covered by french health care system
- •Patients who have given their consent or his family
排除标准
- •Pregnant or lactating women
- •Sevoflurane anaphylaxia
- •Known or suspected risk of malignant hyperthermia
- •Refusal Protocol
- •Brain-damaged patients
- •Hemodynamic conditions not compatible with the use of sevoflurane
- •ARDS patients
- •Minor patients
研究组 & 干预措施
sevoflurane
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Description of the RASS score
时间窗: at day 1
Describe the RASS score corresponding to the values of sevoflurane MAC during sedation of patients in ICU : RASS score determined at the middle of each level of 30 minutes, each level correspond to determined sevoflurane MAC with ascending MAC ranging from 0 to 0.8 and then descending MAC from 0.8 to 0.
次要结局
- determination of the associated hemodynamic and respiratory parameters(at day 1)