Correlation of Eicosanoid and Proresolving Lipid Mediator Temporal Profiles and Resolution of Pain After Thoracic Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 主要终点
- time course of pain resolution after thoracic surgery
研究概览
简要总结
The aim of the current pilot study is to investigate whether perioperative dysregulated systemic lipid mediator pathways (more specifically increased pro-inflammatory and decreased anti-inflammatory pathways) are associated with slower resolution of pain after surgery and increased risk for development of persistent postsurgical pain (PPSP). In addition, we will look for correlations between the pro-resolving lipid mediator profile and Quality of Recovery (QoR-15), duration of hospital stay, and frequency of complications, e.g. wound infections.
详细描述
This is a prospective, observational pilot study that will assess whether 1) a peri-operative dysregulated metabolo-lipidomics or SPM profile is associated with slower resolution of pain after surgery and an increased risk for development of persistent postsurgical pain (PPSP), and 2) whether a peri-operative dysregulated metabolo-lipidomics profile correlates with low Quality of Recovery (QoR-15) scores, duration of hospital stay and frequency of complications, e.g. wound infection.
The study will address the following Specific Aims:
Specific Aim 1: To determine the correlation between the perioperative eicosanoid and pro-resolving lipid mediator temporal profile and day-to-day resolution of pain after thoracic surgery.
We hypothesize that patients who have slower resolution of pain after thoracic surgery have dysregulated systemic lipid mediator pathways when compared to those patients who have faster resolution of pain.
Specific Aim 2: To determine the effectiveness of perioperative SPM signature as a novel predictive marker for the development of persistent pain after surgery (PPSP).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-85
- •Patients scheduled to undergo thoracic surgery at Brigham and Women's Hospital
排除标准
- •Pre-existing chronic pain or opioid use
- •Current treatment with corticosteroids
- •Evidence of active infection
- •Chronic liver disease, end-stage renal disease (CKD-5), or chronic inflammatory disorders
- •Recent major surgery or illness within 30 days
- •Use of immunosuppressive medication
- •History of organ transplantation.
结局指标
主要结局
time course of pain resolution after thoracic surgery
时间窗: 12 months
次要结局
- incidence of persistent pain after thoracic surgery(18 months)
- Quality of Recovery after thoracic surgery(12 months)
研究者
Mieke A. Soens
MD Staff Anesthesiologist
Brigham and Women's Hospital