The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
Not Applicable
- Conditions
- Patients Scheduled for Thoracic Surgery/Esophagectomy Will be EnrolledPersistent Post Surgical Pain
- Interventions
- Dietary Supplement: fractionated marine lipid concentrate derived from anchovy and sardine oil
- Registration Number
- NCT03095157
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain. In addition we will investigate whether treatment with an over the counter dietary supplement containing a fractionated marine lipid derivative from anchovy and sardine oil prevents the development of chronic pain after surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- scheduled to undergo esophagectomy at BWH
- 18-80 years old
Exclusion Criteria
- pre-existing chronic pain
- current opioid use
- current treatment with corticosteroids
- evidence of active infection
- chronic liver disease
- end-stage renal disease (CKD-5)
- chronic inflammatory disorders
- recent major surgery or illness within 30 days
- use of immunosuppressive medication
- history of organ transplant
- pregnancy or plans to become pregnant
- lactating
- allergies to fish or fish oil
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo fractionated marine lipid concentrate derived from anchovy and sardine oil - Treatment fractionated marine lipid concentrate derived from anchovy and sardine oil -
- Primary Outcome Measures
Name Time Method Numeric Rating Scale (0=no pain; 10=worst imaginable pain) at 3 months after surgery 3 months Persistent pain after thoracic surgery
- Secondary Outcome Measures
Name Time Method