NCT03095157
Unknown
Not Applicable
The Emerging Role of Resolvins in the Prevention of Chronic Pain After Thoracic Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients Scheduled for Thoracic Surgery/Esophagectomy Will be Enrolled
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 80
- Primary Endpoint
- Numeric Rating Scale (0=no pain; 10=worst imaginable pain) at 3 months after surgery
- Last Updated
- 9 years ago
Overview
Brief Summary
The aim of the study is to investigate whether pre-operative dysregulated systemic lipid mediator pathways are associated with increased risk for the development of persistent post surgical pain. In addition we will investigate whether treatment with an over the counter dietary supplement containing a fractionated marine lipid derivative from anchovy and sardine oil prevents the development of chronic pain after surgery.
Investigators
Mieke A. Soens
MD Staff Anesthesiologist
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- •scheduled to undergo esophagectomy at BWH
- •18-80 years old
Exclusion Criteria
- •pre-existing chronic pain
- •current opioid use
- •current treatment with corticosteroids
- •evidence of active infection
- •chronic liver disease
- •end-stage renal disease (CKD-5)
- •chronic inflammatory disorders
- •recent major surgery or illness within 30 days
- •use of immunosuppressive medication
- •history of organ transplant
Outcomes
Primary Outcomes
Numeric Rating Scale (0=no pain; 10=worst imaginable pain) at 3 months after surgery
Time Frame: 3 months
Persistent pain after thoracic surgery
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