Randomized controlled clinical trial to evaluate the efficacy of Amrutanagaradi Kwatha in the management of Eka Kushtha (Psoriasis)
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Krushnaaruna Varna (Erythema)
研究概览
简要总结
Intoday’s fast track life style, people are shifting more toward mechanisticworld and are adopting unhealthy dietary and lifestyle choices, which haveresulted in increasing trend of lifestyle diseases. Psoriasis is one amongstthese notorious auto-immune disorders having deep psychological and socialimpacts. It is a chronic inflammatory disease with skin manifestations,aggravated by or can recur by number of triggering factors such aspsychological (anxiety, stress, depression etc.), dietary (incompatible diet),lifestyle disturbances, medications .
Psoriasis word derived from word ‘Psora’ which means‘itch’ or ‘Rash’.
Psoriasis is non-infectious chronic inflammatorydisease of the skin characterized by well-defined erythematous plaque withsilvery scale which have predilection for extensor surfaces and scalp and bychronic fluctuating course.
Kushtha (skin disorders) has been considered amongAshtamahagada (octa- ominous disorders)in Ayurveda. Eka Kushtha is one of the subtypes of Kushtha, which is equatedwith Psoriasis as they show similar manifestations such as Aswedanam(anhydrosis), Mahavastu (extent of lesion), Matsyashakalopamam (scaling).
According to many acharyas in kushta vyadhi all thethree dosas involvement have been seen.
The Lakshanas of Eka Kushtha are Aswedanam,Mahavastu (extent of lession), Mastyashakalopam ( Scaling).
Inindia the Prevalence of Psoriasis varies From 0.44 To 2.8 %.It is twice morecommon in males compare to female and most of the patients are in there thirdor forth decade.
Inayurveda, many herbs have proven efficacy in psoriasis but the multifacetedetiology of disease need multimodal treatment approach.
Theprevalence rate of psoriasis increasing day by day despite having such as highprevalence rate the treatment of psoriasis is still limited so the study isconducted.
Inkushta, there is involvement of tridoshas and Amrutanagaradi Kashaya mentionedin Sahastrayog have great action on all tridoshas and it produces deeper actionon Eka kushta .Therefore study is undertaken to evaluate the efficacy of Amrutanagaradi kwathaon Eka kushtha.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Open Label
入排标准
- 年龄范围
- 20.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients irrespective of gender and religion will be selected.
- •Patients having clinical features of Eka kushtha such as Mahavastu(Extent of lesion) and Matsyashakalopama(Scaling), Aswedanam(Unhydrosis), Krushnaaruna varna(Erythema).
- •Patients showing sign and symptoms of Psoriasis less than 2 years.
排除标准
- •Patients below 20 year and above the age 55 year of age.
- •Patients with pregnancy and lactation.
- •Patients suffering from Psoriatic arthritis, Tinea corporis, Eczema, Lichen planus, Contact dermatitis.
- •Patients on steroids for more than one year.
结局指标
主要结局
Krushnaaruna Varna (Erythema)
时间窗: 45 Days
Matsyashakalopam (scaling),
时间窗: 45 Days
This Symptoms Will Be Reduced
时间窗: 45 Days
次要结局
- Mahavastu(Extent of lesion)(This Symptom Will Be Reduced)