Value of Non-invasively Measured Arterial Stiffness and Central Hemodynamics for Guiding Antihypertensive Treatment in Selected Patient Populations
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Arterial stiffness and central hemodynamics
研究概览
简要总结
Guidelines recommend measuring end organ damage and in particular arterial stiffness in patients with hypertension. However, until now it was not possible to measure arterial stiffness with the use of simple methods. Recently, novel and innovative devices offering determination of arterial stiffness and central hemodynamics from simple and non-invasive arm cuff measurements have now become available. This study therefore evaluates the value of non-invasively measured arterial stiffness and central hemodynamics for guiding antihypertensive treatment in selected patient populations (i.e. elderly patients, patients with diabetes mellitus, patients with heart failure, and patients with resistant hypertension).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients >70 years (elderly cohort)
- •Patients with diabetes mellitus (diabetes cohort)
- •Patients with heart failure (heart failure cohort)
- •Patients with resistant hypertension (resistant hypertension cohort)
排除标准
- •Patient refuses study participation
- •Severe renal failure
- •Reduced life expectancy
结局指标
主要结局
Arterial stiffness and central hemodynamics
时间窗: 3 months
Non-invasive measurement of arterial stiffness and central hemodynamics with the Tensiomed Arteriograph device
Cognitive function
时间窗: 3 months
Measurement with Mini Mental State Exam and Verbal Recall Test
次要结局
- Physical function(3 months)
- Orthostatic hypotension and falls(3 months)
- Renal failure(3 months)
研究者
Prof. Paul Erne
Head of Department of Cardiology
Luzerner Kantonsspital