Effect and mechanism of cangma Pill on airway mucus hypersecretion in patients with stable bronchiectasis based on NE / EGFR / MUC5AC pathway

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

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•The diagnostic standard of dampness syndrome of spleen deficiency is made by referring to the Chinese Medicine Industry standard of the People's Republic of China-Chinese Medicine Syndrome Diagnosis Standard: wheezing cough and chest tightness, sputum is easy to cough, sputum is sticky or spit is not comfortable, the chest is stuffy, the mouth is greasy, stomach cavity and abdominal distension. The tongue is pale, the tongue coating is white and greasy, the pulse string is slippery.
•Inclusion criteria
•1) Patients with stable bronchiectasis diagnosed which conforms to the western medicine and airway mucus hyper-secretion assessment;
•2) Patients with bronchiectasis presented as syndrome of spleen deficiency and dampness in Chinese medicine;
•3) Aged between 18 and 80 years old;
•4) Able to understand and sign the informed consent.

•1)Patients with dry bronchiectasis (clinical symptoms only include hemoptysis);
•2)Patients with acute exacerbation of bronchiectasis (the definition of acute exacerbation is based on the clinical judgment of the expert consensus on the diagnosis and treatment of adult bronchiectasis in 2020 edition);
•3)Complicated with serious cardiovascular and cerebrovascular complications and serious gastrointestinal diseases;
•4)The value of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are 1.5 times higher than the upper limit of normal value, and creatinine (Cr) is more than the upper limit of normal value;
•5)Patients with various organ tumors;
•6)Pregnant and lactating women;
•7)Known allergy to the test drug;
•8)Participated in other clinical trials within three months.

发起方

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University