NCT02615756已完成不适用
Molecular and Functional Neurobiology of Physical Exercise
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Binding of [11C]carfentanil in brain confirmed by positron emission tomography
研究概览
简要总结
In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Native Finnish speaker
- •Age > 18 years
- •Western Caucasian origin
排除标准
- •Age < 18 or > 65
- •History or current mental disorder
- •BMI > 27 kg/m2
- •Use of drugs that influence the central nervous system, including nicotine
- •Poor compliance
- •Any chronic medical defect or injury which hinder or interfere everyday life
- •Eating disorder
- •Current or past excessive use of alcohol or substance abuse
- •Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
- •Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- •Presence of any ferromagnetic objects that would make MR imaging contraindicated
结局指标
主要结局
Binding of [11C]carfentanil in brain confirmed by positron emission tomography
时间窗: Baseline and 20 min after physical exercise completion
Change in binding of \[11C\]carfentanil in baseline and 20 min after physical exercise completion
次要结局
未报告次要终点
研究者
研究点 (2)
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