Volume Parameters Vs Flow Parameters In Assessment Of Reversibility In Stable Chronic Obstructive Pulmonary Disease Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- Assess the response pattern to inhaled short acting B2 agonist
研究概览
简要总结
- Assess the differences between flow and volume responses after bronchodilator reversibility testing in patients over different clinical chronic obstructive pulmonary disease stages (GOLD stage I to GOLD stage IV).
- Study the Correlation between the bronchodilator response and the severity of the disease.
详细描述
chronic obstructive pulmonary disease is a common preventable and treatable disease characterized by persistent airflow limitation that is usually progressive. The diagnosis requires an evidence of obstructive pattern by spirometry measured before and after bronchodilators.
The degree of reversibility of airflow obstruction differs between patients, and does not predict the response to bronchodilator therapy. It can be seen in terms of forced vital capacity (FVC) or forced expiratory volume in the first second (FEV1),or Inspiratory capacity (IC) or residual volume (RV).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients Clinical diagnosis of Chronic Obstructive Pulmonary Disease
- •Must be able to do pulmonary function test
- •Age more than 40 years
- •Stable Chronic Obstructive Pulmonary Disease patients
排除标准
- •Any patients with a diagnosis of:
- •Bronchial asthma
- •Bronchiectasis
- •Respiratory failure
- •Decompensated core pulmonale
- •Chronic Obstructive Pulmonary Disease combined with any other respiratory disease
研究组 & 干预措施
Whole body plethysmography
干预措施: Whole body plethysmography (Diagnostic Test)
spirometery
干预措施: Whole body plethysmography (Diagnostic Test)
结局指标
主要结局
Assess the response pattern to inhaled short acting B2 agonist
时间窗: twice per day one before inhaled short acting B2 agonist and one after 10 minutes from inhaled short acting B2 agonist for average of 2 year
Assess the response pattern to inhaled short acting B2 agonist through measuring flow and volume parameters to define the differences between volumes responders and flow responders
次要结局
未报告次要终点
研究者
Azza Bahaa El-Din Ali Mohamed
Principal Investigator
Assiut University