ISRCTN96078487已完成不适用
Medical Management of Severe Aortic Regurgitation in Asymptomatic Patients with Normal Left Ventricular Function with Valsartan - A Study to Assess Disease Progressio
Record Provided by the NHSTCT Register - 2006 Update - Department of Health0 个研究点目标入组 0 人开始时间: 2006年9月29日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Subjects are to be recruited from patients either under active follow-up or active referral as in-patients or out-patients to the Department of Cardiology, University Hospital Birmingham.
- •1. Asymptomatic or mildly symptomatic patients with moderate - severe AR (NYHA II or less; CSA <2)
- •2. Normal LVEF >50%
- •3. Preserved LV dimensions (LVIDs <5.5cm)
排除标准
- •1. Acute, severe AR or rapid deterioration of AR (within the preceding six months)
- •2. Mixed aortic stenosis and regurgitation (valve stenosis > mild defined as peak gradient above 20 mm Hg)
- •3. Evidence of additional valvular or congenital heart disease on echocardiographic study sufficient to require surgical intervention
- •4. Abnormal left ventricular ejection fraction (<50 percent)
- •5. Contra-indications to Angiotensin II receptor antagonist therapy (previous intolerance; known or suspected renovascular hypertension; creatinine >150 umol/L, serum potassium > 5.9 mmol/l) or to treatment with nifedipine
- •6. Contra-indication to cardiac MRI
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