ISRCTN10706683进行中（未招募）Unknown
iothyronine to normalise Thyroid Hormones in Heart Failure (T3-HF) - A feasibility study
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 入组人数
- 25
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Men and women aged between 18 – 80 years
- •2. Stable HFrEF (no admission to hospital with HF exacerbations in the previous 3 months)
- •3. Chronic HFrEF (diagnosed more than 3 months prior to recruitment)
- •4. Moderate – severe systolic left ventricular dysfunction (LVEF < 45% on cardiac echocardiogram within last 6 months)
- •5. On standard HFrEF therapy
- •6. With low serum T3 levels (< 3.5 pmol/L)
排除标准
- •1. Those on medications affecting thyroid function (such as levothyroxine, antithyroid drugs, amiodarone, lithium and sodium valproate)
- •2. Patients admitted to hospital with acute exacerbation of HF in the preceding 3 months
- •3. Claustrophobia precluding cardiac magnetic resonance (MR) assessment
- •4. Cardiac devices (such as implantable cardioverter defibrillators) that are incompatible with MR scanning
- •5. Untreated valvular heart disease as the main cause of the HFrEF
- •6. With severely abnormal serum TSH (< 0.1 or > 10.0 mIU/L) or thyroxine (FT4) levels (< 9.0 or > 23.0 pmol/L)
- •7. Participants who are unable to provide written informed consent
- •8. Individuals who are pregnant or trying to conceive
研究者
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