Comparison of efficacy of nebulized lignocaine with intravenous lignocaine for attenuation of pressor response to laryngoscopy and intubation.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Evaluation of efficacy of the NL as compared to IVL in suppressing pressor response to laryngoscopy and intubation
研究概览
简要总结
Despite adequate anaesthetic depth, direct laryngoscopy and intubation elicita significant adreno-sympathetic response. This response, as manifested byincreased blood pressure (BP), heart rate (HR), arrythmias etc. Lignocaine givenintravenous or topically (nebulization) attenuates pressor responses tolaryngoscopy and intubation. Very few studies lignocaine by nebulization hasbeen done to evaluate the effect on pressor responses.
The present study was undertaken to compare the efficacy of intravenouslignocaine 2%versus efficacy of nebulized lignocaine before induction ofanaesthesia in attenuating the pressor response to direct laryngoscopy andendotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 63.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA 1 and 2 patients posted for surgery under general anaesthesia requiring endotracheal intubation.
排除标准
- •Patients with pre existing hypertension, Patients with known allergy to the study drug or contraindication to any of the administered drugs, Patients with anticipated difficult airway, Patients who refused or inability to understand the procedure.
- •5.Patients who are smokers 6.Patients with History of respiratory distress 7.Patients with gastroesophageal reflux,Neurological ,cardiovascular,respiratory ,hepatic or renal dise.
结局指标
主要结局
Evaluation of efficacy of the NL as compared to IVL in suppressing pressor response to laryngoscopy and intubation
时间窗: Starting of nebulized lignocaine/Intravenous lignocaine to 20th minute after endotracheal intubation.
次要结局
- Evaluation of efficacy of the 2% lignocaine nebulization for 20minutes as compared to 1.5mg/kg intravenous lignocaine bolus in(suppression of arrhythmias/any other complications if any during laryngoscopy and intubation.)