Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- anterograde episodic memory: 3 scores of emotional ESR
研究概览
简要总结
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. Various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression.
The main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in MS patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women 30-60 years of age
- •Definite MS (McDonald criteria revised in 2005)
- •Sick Shapes: Relapsing multiple sclerosis, Primary progressive multiple sclerosis
- •All durations evolution
- •French Mother tongue
- •Signature of informed consent
排除标准
- •Other neurological conditions, previous psychiatric or developmental diagnosis of MS
- •Head injury sequelae
- •Chronic alcohol or drugs Taking
- •EDSS greater than or equal to 6
- •Secondary Progressive Form
- •Push and / or treatment with corticosteroids within one month
- •Treatments Amantadine, Modafinil introduced for less than 3 months
- •Patient Trust
- •Cognitive Assessment of less than one year (including in particular all or part of the balance sheet proposed in this project)
- •Any visual motor deficit or incompatible with the award of cognitive tests
- •For women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the PET scan)
- •Patient with indications against MRI
结局指标
主要结局
anterograde episodic memory: 3 scores of emotional ESR
时间窗: baseline
3 scores of emotional ESR
retrograde episodic memory: 9 scores TEMP emotional
时间窗: baseline
9 scores TEMP emotional
次要结局
未报告次要终点