Effects of Varenicline and Cognitive Bias Modification on Neural Response to Smoking Cues - Varenicline and Cognitive Bias Modification on Smoking Cue Response

niversity of Bristol0 个研究点目标入组 89 人开始时间: 2012年1月5日最近更新: 2019年11月25日

试验速览

暂无简介。

•Smokes > 10 manufactured cigarettes or > 15 roll up cigarettes per day. • Smokes within one hour of waking. • Aged between 18 and 40 years. • Able to attend all of the study sessions. • English as first language or equivalent level of fluency. • Able to give informed consent as judged by lead researcher.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 72
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range 0

•Female volunteers who are pregnant or breast feeding. • Female volunteers not using adequate contraception. • Volunteers who do not currently have a GP. • Current or previous substance or alcohol misuse or dependence [other than nicotine] Alcohol use in excess of 35 Units/week if female or 50 Units/week if male. • Caffeine use = 8 cups per day. • Significant current or past psychiatric illness (Axis 1 or 2 psychiatric diagnoses) as diagnosed by a psychiatrist. • Clinically significant abnormality including cardiology risk factors and history of arrhythmia (as assessed by self-report). • Ongoing use of medication (i.e. intake of any medication within 8 weeks of study, with exception of local treatment and occasional paracetamol or non-steroidal anti-inflammatory drugs, e.g., aspirin or ibuprofen). • Smokers actively trying to give up smoking during the study period. • Uncorrected visual impairment (including colour-blindness). • Uncorrected auditory impairment. • Condition that make MRI scanning unsafe (e.g. metallic implants; history of metal-working). • Unable to tolerate scanning environment (as established during a short anatomical MRI scan on day 0). • Hypersensitivity to Champix.

发起方

niversity of Bristol