Pediatric Ards Neuromuscular blockade (PAN) study: Life-threatening acute respiratory failure in children: to breathe or not to breathe spontaneously, that's the question. - PAN study

Beatrix Children's Hospital, University Medical Center Groningen0 个研究点目标入组 178 人开始时间: 2017年12月6日最近更新: 2019年4月30日

试验速览

暂无简介。

•- Informed consent
•- Age younger than 5 years
•- Need for invasive mechanical ventilation with PEEP 5 cmH2O
•- Early moderate – to – severe paediatric acute respiratory distress syndrome originating from any cause: - Acute onset of disease, and - Oxygenation index > 12, and - One or more (bilateral) infiltrates on chest radiograph, and - No evidence of left ventricular failure or fluid overload, and - Within the first 96 hours of PICU admission
•- Sedation defined by Comfort – B scale between 11 - 17
•Are the trial subjects under 18? yes
•Number of subjects for this age range: 178
•F.1.2 Adults (18-64 years) no
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- No informed consent
•- Known allergy or intolerance to rocuronium
•- Continuous administration of neuromuscular blockade prior at the time of meeting the criteria for paediatric acute respiratory distress syndrome
•- Bolus administration of neuromuscular blockade within 1 hour before meeting PARDS criteria
•- Chronic respiratory failure on home ventilation
•- Intracranial hypertension
•- Bone marrow transplantation
•- Pre-existing pulmonary hypertension
•- Congenital heart disease with left - to - right shunting
•- Cyanotic congenital heart disease
•- Expected duration of mechanical ventilation less than 48 hours
•- Withdrawal of life–sustaining treatment

发起方

Beatrix Children's Hospital, University Medical Center Groningen