NCT02062008终止不适用
Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
研究概览
简要总结
The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.
详细描述
- To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease.
- To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease.
- To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction.
- To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods
- To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis.
- To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation.
- To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging.
排除标准
- •Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%.
研究组 & 干预措施
Cardiac patients receiving PET/MR
Other
PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour.
干预措施: PET-MRI (Device)
结局指标
主要结局
Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
时间窗: 2 hours
Visual analysis of collected image pairs. Evaluated by experienced imaging providers as yes or no.
次要结局
未报告次要终点
研究者
研究点 (1)
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