NCT03999528已完成不适用
14-3-3η Protein, Disease Activity and Bone Mineral Density, in Female Patients With Rheumatoid Arthritis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- 14-3-3η Protein and RA disease activity
研究概览
简要总结
Is to investigate the relation between 14-3-3η protein, disease activity, and bone mineral density in female patients with rheumatoid arthritis.
详细描述
Methods: all patients in the study will subject to:
- Clinical assessment, WT, Height ,BMI, parity, medications,
- DAS 28.
- Serum 14-3-3η protein.
- DEXA scan.
Grouping:
- Group I: RA Patients with low BMD.
- Group II: RA Patients with normal BMD.
- Group III: normal control.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Rheumatoid arthritis according to ACR 2010 criteria with at least one year duration.
- •Premenopausal females.
- •On conventional DMARD with maximum 5 mg steroids.
排除标准
- •Biological treatment.
- •Previous antiresorptive treatment, or bone anabolics.
- •High dose corticosteroid.
- •Chronic renal or kidney disease.
- •Medications affecting bone metabolism.
- •Thyroid or adrenal dysfunction,
结局指标
主要结局
14-3-3η Protein and RA disease activity
时间窗: three months
percent of active RA disease and study the correlation between 14-3-3η Protein and RA disease activity
次要结局
- 14-3-3η Protein and osteoporosis in RA patients(three months)
研究者
Ahmed Abogamal
Professor
Al-Azhar University
研究点 (1)
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