DRKS00013101已完成未知
Functional MRI assessment of arterial and cardiopulmonary baroreflexes and hypoxic/hyperoxic chemoreflexes in the human brainstemPilot study
Deutsches Zentrum für Luft- und Raumfahrt (DLR), Institut für Luft- und Raumfahrtmedizin, Abteilung Kardiovaskuläre Luft- und Raumfahrtmedizin (KLM)0 个研究点目标入组 12 人开始时间: 2017年12月11日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 12
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 40 Years（—）
- 性别
- Male
入选标准
- •Physically and mentally healthy male test subjects that are able and declare in writing their willingness to participate in the entire study and successfully passed the psychological and medical screening
- •Aged between 18-40 years old with a Body Mass Index (BMI) of 19-28 kg/m2, weight between 60-100 kg, and a height between 160-195 cm
- •Non-smoker, for at least six months before the start of the study
- •Demonstrable medical insurance
- •Normal blood pressure (lower than 140 over 90)
- •intact pharmacological baroreflex heart rate response for continuing fMRI study
- •inconspicuous routine diagnostic laboratories concerning endocrine diseases, renal or hepatic dysfunction, autoimmune diseases, musculoskeletal diseases
排除标准
- •Medical history is assessed during medical inclusion.
- •1. Neurological conditions including strokes, brain haemorrhage, aneurysms, brain tumours, neurodegenerative diseases, seizures, head trauma based on medical history.
- •2. Cardiopulmonary conditions including coronary artery disease, myocardial infarction, heart failure, ventricular or atrial arrhythmias, pacemaker, recurrent syncope, autonomic disorders, chronic pulmonary diseases (COPD, severe asthma, pulmonary fibrosis), sleep apnea, insomnia or narcolepsy based on medical history. Diseases with compensatory hypertension (e.g. coarctation of the aorta, arteriovenous shunting).
- •3. Active or previous psychiatric conditions including depression, anxiety, bipolar disorder, ADHD based on medical history.
- •4. Any other medical condition that the investigators consider a contraindication to the study procedures that would make it unsafe or confound the measurements. This includes, for instance, drug, medication or alcohol abuse (regular consumption of more than 20-30 g alcohol/day), migraine, or taking medications that may impair cognitive function, autonomic function or any of the study procedures.
- •5. Congenital (Leber’s) optic atrophy or tobacco amblyopia.
- •metal implants or active medical devices
研究者
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