External Evaluation of Vancomycin Population Pharmacokinetic Models and Development of Continuous Infusion Dosing Recommendations
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Imprecision in Predictive performance of seven pharmacokinetic models
研究概览
简要总结
All patients treated with vancomycin hospitalized outside of ICU in Brest University Hospital from 1rst january 2019 to 1rst january 2021 will be screened for inclusion. Vancomycin dosage, age, weight and serum creatinin will be recorded.
Seven pharmacokinetic models' predictive performance will be evaluated on this database.
Using the best model, we will perform Monte-Carlo simulation to elaborate dosing nomograms and develop dosing recommandations of continuous infusion of vancomycin.
详细描述
Monte Carlo simulations will be performed according to varying creatinin clearance values and weight, for both the loading dose and the maintenance dose.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients hospitalized in Brest University Hospital,
- •treated with vancomycin and receiving pharmacological monitoring
- •between 1rst January 2019 and 1rst January 2021
排除标准
- •Missing data on vancomycin administration
- •Refusal to be included in this study
- •Hospitalisation in ICU
结局指标
主要结局
Imprecision in Predictive performance of seven pharmacokinetic models
时间窗: September 2021
The model with the lesser imprecision reported on the Observed vs Predicted Concentrations Graph will be selected
Bias in Predictive performance of seven pharmacokinetic models
时间窗: September 2021
The model with the lesser bias reported on the Observed vs Predicted Concentrations Graph will be selected
次要结局
未报告次要终点