Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Changes in cardiac index after volume expansion
研究概览
简要总结
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
详细描述
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
When there are clinical signs of hypovolemia, such as hypotension, decreased urine output and central venous pressure less than 5 mmHg, right upper abdomen is gently compressed for 10 seconds. Changes of blood pressure are continuously recorded during this period. About 3 min later, intravenous colloid fluid 10 mL/kg is infused for 20 min.
To evaluate the change of cardiac output, transesophageal or transthoracic echocardiography is performed before and after fluid administration. In addition, hemodynamic parameters including pulse pressure variation, systolic pressure variation, pleth variability index and central venous pressure are also recorded before and after fluid administration.
Finally, patients will be divided into fluid responder group and non-responder group. If cardiac output measured using echocardiography increases over 15% after fluid administration, the patient is fluid responder. Using ROC curve, diagnostic power of abdominal compression-induced blood pressure change for fluid responsiveness will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 1 Month 至 5 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Pediatric patients undergoing elective surgery, who require invasive blood pressure and central venous pressure monitoring during surgery
排除标准
- •renal, hepatic and pulmonary disease
- •preoperative infection: increased CPR, WBC over 10,000, and with fever
- •genetic and hematologic disease
- •intracardiac and extracardiac shunt
- •single ventricle
- •right heart dysfunction
- •any intracardiac valve pathology
- •increased intracranial pressure
结局指标
主要结局
Changes in cardiac index after volume expansion
时间窗: before and after fluid administration (20 min)
次要结局
- Changes in pleth variability index after volume expansion(before and after fluid administration (20 min))
- Changes in respiratory changes of peak aortic blood flow velocities after volume expansion(before and after fluid administration (20 min))
研究者
Jin-Tae Kim
Associated professor
Seoul National University Hospital