NCT06827197已完成不适用
Role of Interleukin-1β and Prostaglandin E2 in Prediction and Outcome of Apnea in Neonates
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Duration of NICU stay
研究概览
简要总结
Our thesis proposed that IL-1β may affect brainstem respiratory control via prostaglandin-dependant mechanism so we investigated the mediator roles of IL-1β and PGE2 levels in predicting apnea in pretertm newborn and their relation to clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 2 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preterm infants born at less than 37 weeks of gestation.
- •Neonates aged from birth up to 28 days.
- •Neonates diagnosed with apnea of prematurity or exhibiting apneic episodes
排除标准
- •Full-term neonates.
- •Neonates with major congenital malformations or genetic syndromes.
- •Neonates with severe neurological impairments (e.g., intraventricular hemorrhage grade III or IV).
- •Neonates with confirmed or suspected sepsis or active infections.
- •Neonates receiving steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), or other medications known to alter interleukin-1β or prostaglandin E2 levels.
- •Neonates with congenital heart diseases.
- •Neonates with a history of significant birth asphyxia requiring extensive resuscitation.
- •Neonates whose parents or guardians refuse to provide informed consent.
结局指标
主要结局
Duration of NICU stay
时间窗: 1 month
Mortality rate
时间窗: 1 month
次要结局
未报告次要终点
研究者
Amany Mohammed El-Rebigi, MD
Lecturer of Pediatrics, Faculty of Medicine, Benha University, Benha, Egypt
Benha University
研究点 (2)
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