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临床试验/NCT07219498
NCT07219498招募中不适用

Effects of a 5-Week Probiotic Supplementation Intervention on Markers of Delayed Onset Muscle Soreness

University of Minnesota1 个研究点 分布在 1 个国家目标入组 24 人开始时间: 2026年2月5日最近更新:
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
24
试验地点
1
主要终点
Change in perceived muscle soreness

研究概览

简要总结

The purpose of this study is to evaluate how probiotic supplementation (PS) influences post-exercise recovery in healthy, physically active young adults. Researchers aim to determine if the Lactobacillus casei probiotic strain reduces symptoms of delayed onset muscle soreness (DOMS) based on perceived muscle soreness, pressure pain threshold, and power output following exercise induced muscle damage (EIMD).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • complete a minimum of 150 minutes a week of at least moderate intensity exercise in either an endurance-based or resistance-based training style based on a self-reported physical activity over the past month
  • good general health with no injuries or health conditions that would affect physical activity
  • willing to abstain from consistent NSAID use and other probiotic supplements over the course of this study

排除标准

  • known musculoskeletal injuries or physical limitations that could interfere with performing the designated physical activity required
  • underlying conditions that could place them at an increased risk during exercise such as cardiovascular, respiratory, or metabolic diseases
  • currently take a probiotic supplement, are prescribed and taking an antibiotic during the intervention, or report using NSAIDs or steroids within the recovery time window
  • report using an NSAID more than twice a week on a regular basis

研究组 & 干预措施

Probiotic Group

Active Comparator

干预措施: Lactobacillus casei (Dietary Supplement)

Placebo Group

Placebo Comparator

干预措施: Placebo Capsule(s) (Other)

结局指标

主要结局

Change in perceived muscle soreness

时间窗: From baseline to post 5-week intervention

Visual Analog Scale for perceived muscle soreness Each number on the scale will be designated with a descriptive word that corresponds to the soreness level they are experiencing. The scale will be laid out in order of increasing muscle soreness with "1" representing no pain.

Change in pressure pain threshold (PPT)

时间窗: From baseline to post 5-week intervention

Calf pressure pain threshold (PPT) will be assessed by placing marks on the medial condyle of the femur and the posterior of the medial malleolus. The researcher will place the algometer on the muscle belly exactly halfway between the two marks. Volunteers will be instructed to specify when the first onset of pain occurs as the researcher gradually applies pressure. Quadricep measurements will involve the participant lying in the supine position where marks will be made on the anterior inferior iliac spine and the top of the patella so the researchers can once again find a point exactly halfway between these two locations to apply the algometer. Participants will be instructed to verbally indicate to the researcher when the onset of pain occurs as pressure is applied.

Change in countermovement jump assessment (CMJ) performance recovery

时间窗: From baseline to post 5-week intervention

The researchers will demonstrate and instruct volunteers to "Stand upright with their hands above their head. When you are ready, bend your knees and stick your hips back while keeping your hands to your hips. Jump as high as possible and land softly." Participants will perform three CMJs separated by 60 seconds. Jump height will be recorded in cm and the highest value will be recorded.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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