Study of the Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 726
- 试验地点
- 2
- 主要终点
- PIPR : Post-Illumination Pupil Response
研究概览
简要总结
The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by "classical" retina photoreceptors which allow vision (rods, cones) but also melanopsin cells. The non-visual effects of light seems to be altered in many neurological, psychiatric or ophtalmological conditions but their exact role in the pathogenesis remains poorly understand. The purpose of the study is to increase our knowledge of the non-visual effects of light and establish new therapeutic applications
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Man or woman
- •Aged 18 years or older
- •Subject having signed a free and informed consent
- •Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject
排除标准
- •Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes)
- •Cataract with significant vision loss <5/10
- •Chorioretinal neovascularization
- •Subject in exclusion period determined by previous or current study
- •Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...)
- •Subject under the protection of justice
- •Subject under guardianship or curatorship
- •Pregnancy / Breastfeeding
研究组 & 干预措施
neurological pathology
subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep
干预措施: Specific light exposures (Other)
psychiatric pathology
subject presenting a psychiatric pathology with disorder of the controls of the wake and the sleep
干预措施: Specific light exposures (Other)
ophthalmological pathology
subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction
干预措施: Specific light exposures (Other)
photosensitivity
subjects with photosensitivity with regulation disorder of sleep and wake
干预措施: Specific light exposures (Other)
group control
healthy subject
干预措施: Specific light exposures (Other)
primary sleep-wake disorder
Subjects with primary sleep-wake disorder
干预措施: Specific light exposures (Other)
结局指标
主要结局
PIPR : Post-Illumination Pupil Response
时间窗: 1 day
1 measurement per subject is performed after exposure to monochromatic light exposure
次要结局
未报告次要终点