Evaluation of the acute effects of oral nutrients on gastric emptying, small intestinal transit, gastrointestinal hormones and appetite in humans in healthy males versus overweight and obese males

A/Prof Christine Feinle-Bisset0 个研究点目标入组 30 人开始时间: 2010年2月3日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•Subjects will all be males between age 18 -56 years, with a body mass index (BMI) of 18 - 25 kg/m2 for lean, 25 - 30 kg/m2 for over-weight and between 30 -35 kg/m2 for obese. Lean subjects will be required to be unrestrained eaters. All other subjects would have to had consume less than 20g of alcohol per week, be non-smokers, free of gastrointestinal or chronic disease and not currently taking medication.

•Each subject will be questioned prior to the study to exclude: (1)significant gastrointestinal symptoms; disease or surgery (2)current use of medications which may alter gastrointestinal motor function or appetite (3)diabetes mellitus (fasting glucose >6.9 mmol/l and/or glycated haemoglobin >6.2 %) (4)epilepsy (5)cardiovascular or respiratory disease (6)any other significant illness as assessed by the investigator (7)allergy to local anaesthetic (8)intake of > 20 g alcohol on a daily basis (9)smokers (10)individuals with food intolerances, allergies or vegetarians

发起方

A/Prof Christine Feinle-Bisset