ISRCTN83972743已完成不适用
Autologous human bone marrow stem cells mobilized by granulocyte colony-stimulating factor (G-CSF) to improve liver function in patients with decompensated alcoholic liver disease: a randomized study
Foundation for Liver and Gut Studies (FLAGS) (Switzerland)0 个研究点目标入组 60 人开始时间: 2008年3月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age 18-75 years
- •2. Biopsy-proven alcoholic liver disease
- •3. Abnormal liver function with a Model for End-Stage Liver Disease (MELD) (assessment that include bilirubin, coagulation time and creatinine) score 10-26
- •4. Written informed consent
排除标准
- •1. Recent (10 days) infection or hemorrhage
- •2. Estimated survival <6 months
- •3. Coexistent HIV, hepatitis C virus (HCV), hepatitis B virus (HBV)
- •4. Portal vein obstruction
- •5. Documented hepatocellular carcinoma
- •6. Severe liver atrophy as defined by volumetry <0.6% body weight
- •7. Leucocytes >25g/L
- •8. Known hypersensitivity to G-CSF
- •9. Creatinine >150 µmol/L
- •10. Contraindication to arteriography
- •11. Clinically overt hepatic encephalopathy
- •12. Absence of written consent
研究者
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