Effect of Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 2
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Change in blood pressure
研究概览
简要总结
Flavanols are plant-derived compounds commonly present in the human diet. Examples of flavanol-containing foods and beverages are apples, chocolate, tea, wine, berries, pomegranate and nuts. The consumption of flavanol-containing foods and beverages has been associated with improvements in cardiovascular health. In this study, the investigators hope to learn more about the effects of long term consumptions of cocoa flavanols on blood pressure, platelet function and other metabolic parameters in healthy humans. This study is a continuation of a previous study investigating the consumptions of increasing amounts of cocoa flavanols on blood pressure, platelet function and other metabolic parameters in healthy humans
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •30-55 years old
- •A normal blood chemistry and liver function
- •BMI < 30 kg/m2
- •previously consumed cocoa and peanut products, with no adverse reactions
排除标准
- •A history of cardiovascular disease, stroke, hypertension, renal, hepatic, or thyroid disease, GI tract disorders, previous GI surgery, metabolic syndrome, diabetes, taking cholesterol-lowering medication, hormone replacement therapy, antioxidant supplements, on aspirin therapy or taking anticoagulants, or on a medically prescribed diet.
- •Allergies to nuts, cocoa and chocolate products
- •Vegetarian, Vegan, food faddists, individuals using non-traditional diets, on a weight loss diet or using herbal dietary supplements
结局指标
主要结局
Change in blood pressure
时间窗: Baseline (day 0) and 6,12 and 14 weeks after intervention
Blood pressure will be measured using standard techniques.
次要结局
- Change in platelet function(Baseline and 6, 12 and 14 weeks after intervention)
- Change in 24 h ambulatory blood pressure(Baseline (day 0) and 12 weeks after intervention)
- Change in metabolic parameters in blood(Baseline (day 0) and 6, 12 and 14 weeks after intervention)