Effects of Sucralose Consumption on Glucose Metabolism, Incretin and Gut Microbiota in Healthy Adult
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- The effect of sucralose on insulin secretion
研究概览
简要总结
Hypothesis:
- Long-term consumption of sucralose may effect glucose metabolism, incretin hormone secretion and gut microbiota in healthy adults.
- Long-term consumption of sucralose may alter food behaviour in healthy adults.
详细描述
Artificial sweeteners such as sucralose, are among the most widely used food additives worldwide. Artificial sweetener consumption is considered safe and beneficial owing to their low caloric content. However, many emerging evidences showed artificial sweeteners may induce glucose intolerance. The objectives of this study were to determine the effect of sucralose on glycemic response, insulin secretion, insulin sensitivity, incretin response, gut microbiota and food behavior in healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers without underlying disease
- •Normal oral glucose tolerance test
- •Agree to participate by written informed consent
排除标准
- •Shift workers
- •History of diabetes mellitus or prediabetes (impaired fasting glucose and/or glucose tolerance test)
- •Malabsorption problem
- •Regular consumption of nonnutritive sweeteners
- •Liver impairment (aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) > 3-folds upper normal limit)
- •Renal impairment (serum creatinine >1.5 mg/dL)
- •Use of medications affecting glucose level such as glucocorticoid, estrogen, androgen
- •Pregnant and lactating woman
- •Smoking within 6 months
结局指标
主要结局
The effect of sucralose on insulin secretion
时间窗: 2 hours
We will measure plasma insulin concentrations before and at 0, 2, 3, 4, 5, 6, 8, 10 minutes after administered intravenously 50%glucose 0.3 g/kg within 1 minute. All these data collected were used to calculate acute insulin response to glucose.
次要结局
- Gut microbiota(4 weeks)
- Glucagon-like peptide-1 secretion(2 hours)
- Food record(4 weeks)
- The effect of sucralose on insulin sensitivity(2 hours)
研究者
Chutintorn Sriphrapradang
Assistant Professor
Ramathibodi Hospital