Is There a Relationship Between Hyperlipidemia and Periodontitis?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 160
- 主要终点
- Total cholesterol (TC)
研究概览
简要总结
The aim of present study is to investigate any relationship between hyperlipidemia and periodontal disease regarding the periodontal parameters and plasma lipid parameters, along with age, gender, brushing habit, body mass index, dietary habit, physical activity, alcohol consumption.
In this cross sectional study, a total of 160 individuals were divided into two groups based on their metabolic status: hyperlipidemic group (n=97) and normolipidemic group (n=63). Plaque index, gingival index, bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL) clinical parameters and community periodontal index of treatment needs (CPITN) scores were measured. Triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) levels had been determined previously during individuals routine systemic examinations. Daily brushing habits and interdental cleaning together with dietary habits, alcohol consumption and physical activity levels were also recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects having no periodontal treatment within previous 6 months,
- •number of natural teeth ≥ 10,
- •no history of cancer and systemic disease that affects lipid levels or periodontium,
- •no history of medical treatment for hyperlipidemia, BMI< 30 kg/m2,
- •no pregnancy,
- •no history of systemic antibiotic treatment within previous 3 months,
- •no smoking.
排除标准
- •patients with history of systemic disease that affects lipid metabolism or periodontal disease
- •history of medical treatment for hyperlipidemia
- •pregnancy, lactation or hormone replacement therapy at the time of study
- •use of any other drug known to affect lipid metabolism or periodontal disease
- •systemic infection or any history of systemic antibiotic treatment in previous 3 months
- •smokers as well as ex-smokers
结局指标
主要结局
Total cholesterol (TC)
时间窗: day 0
Subjects with plasma TG or TC levels \> 200 mg/dl and LDL-C levels \> 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits
Low density lipoprotein cholesterol (LDL-C)
时间窗: day 0
Subjects with plasma TG or TC levels \> 200 mg/dl and LDL-C levels \> 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits
Triglyceride (TG)
时间窗: day 0
Subjects with plasma TG or TC levels \> 200 mg/dl and LDL-C levels \> 130 mg/dl were included in the hyperlipidemic group, while the normolipidemic group comprised of patients with plasma TG or TC levels below the aforementioned limits
次要结局
- Clinical attachment level(day 0)
- Gingival index(day 0)
- Bleeding on probing(day 0)
- Plaque index(day 0)
- Probing depth(day 0)
- Community Periodontal Index of Treatment Needs score(day 0)