Effect of Non-surgical Periodontal Therapy on Leptin and Visfatin Expression in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Utilizing ELISA and Real Time PCR
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- visfatin levels in gingival tissues
研究概览
简要总结
- Are adipokines involved in pathogenesis of periodontal disease in diabetic patients?
- Does their level change after periodontal therapy?
详细描述
Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 54 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diabetic patients having diabetes mellitus ≥5 years prior to the study.
- •chronic periodontitis with clinical attachment loss > 5 mm.
- •otherwise systemically healthy subjects.
排除标准
- •any known systemic diseases other than diabetes.
- •pregnancy or lactation.
- •receiving periodontal treatment in the last 6 months.
- •taking any drugs or medications other than anti-diabetic drugs.
研究组 & 干预措施
non-surgical therapy
non-surgical periodontal therapy with ultrasonic scalers and periodontal curettes
干预措施: non-surgical periodontal therapy (Procedure)
结局指标
主要结局
visfatin levels in gingival tissues
时间窗: 3 months
estimation of protein and gene expression of visfatin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..
leptin levels in gingival tissue
时间窗: 3 months
estimation of protein and gene expression of leptin in patients with chronic periodontitis only and diabetic patients with periodontitis before and after non-surgical periodontal therapy..
次要结局
- pocket depth(3 months)
- clinical attachment level(3 months)
研究者
Noha Ayman Ghallab
Associate Professor of periodontology, faculty of oral and dental medicine
Cairo University