Differential Acute Tolerance Development to Effects of Nitrous Oxide
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Pain intensity, pain bothersomeness
研究概览
简要总结
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine differential acute tolerance development to effects of nitrous oxide in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 37 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
30% nitrous oxide
干预措施: Nitrous oxide (Drug)
20% nitrous oxide
干预措施: Nitrous oxide (Drug)
0% Nitrous oxide
干预措施: Nitrous oxide (Drug)
10% nitrous oxide
干预措施: Nitrous oxide (Drug)
40% nitrous oxide
干预措施: Nitrous oxide (Drug)
结局指标
主要结局
Pain intensity, pain bothersomeness
时间窗: 25, 70, & 115 min of inhalation and 40 min post
Subjects will inhale varying conc of nitrous oxide for 120 min with cold immersion of forearm at 25, 70, and 115 min and 40 min after inhalation. Pain intensity and bothersomeness will be assessed at each immersion.
次要结局
未报告次要终点