Critical Care Ultrasound Oriented Shock Treatment in ICU
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- 28-day mortality
研究概览
简要总结
Objective
To investigate whether critical care ultrasound oriented shock management in shock patients in intensive care unit(ICU) can improve outcome.
Methods
Randomized controlled research. Patients were randomly allocated to two groups. In the critical care ultrasound oriented shock management group (CUSS group), treatment was oriented by the findings of critical care ultrasound in each shock phase, while in the control group the decisions about the monitoring and management were made by the clinical team. The goal of treatments in both groups were decreasing lactate by 20% or more per 2 hours for the Optimization phase in shock management, and no increase lactate level when removing the fluid in de-escalation phase. The primary outcome measure were hospital mortality and 28-day mortality, the secondary outcome measure were the length of ventilation and the length of ICU stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SBP <90 mm Hg or MAP <65 mm Hg or SBP decrease >40mmHg or need vasoactive drugs；
- •Skin that is cold and clammy，capillary refill time >4.5s，urine output of<0.5ml/Kg.hr and lactate >2mmol/L；
- •SHOCK presented within 6 hr.
排除标准
- •<18 years old；
- •Pregnancy；
- •Patient or family member refuse to be enrolled.
研究组 & 干预措施
control group
usual care
critical care ultrasound
Circulation management will be adjusted according to the results of critical ultrasound combined with clearance of lactic acid in patients with shock.
干预措施: Critical care ultrasound (Other)
结局指标
主要结局
28-day mortality
时间窗: through study completion,an average of 28 days
28-day mortality
次要结局
- the incidence of AKI(through study completion,an average of 28 days)
- the total length of hospital stay(through study completion,an average of 28 days)
- the length of ICU stay(through study completion,an average of 28 days)
研究者
tongjuan ZOU
Professor
West China Hospital