NL-OMON24362尚未招募不适用
Single-cell analysis of somatic mutations to understand and improve hematopoiesis after transplantation
Princess Máxima Center for Pediatric Oncology0 个研究点目标入组 20 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •(1) Allogeneic HSCT with bone marrow cells from a healthy sibling donor; (2) Age at HSCT <18 yrs; (3) First HSCT; (4) Availability of viably frozen donor bone marrow cells from the Biobank of the UMC Utrecht; (5) >95% donor chimerism; (6) No major HSCT-related complications (see exclusion criteria).
排除标准
- •(1) Major HSCT-related complications, such as >grade 2 graft versus host disease; (2) Secondary graft failure; (3) Objection to be notified about actionable findings from whole-genome sequencing; (4) Failure of the HSCT recipient, donor and/or their legal representatives to understand the patient information and informed consent form (either due to intellectual disability or to language problems). Of note: Only include subjects in whom both the HSCT recipient and his/her donor (and, if applicable, their caregivers) agree to participate in the current study are eligible.
研究者
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