The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months.
研究概览
简要总结
Prevention of dental caries has taken a great importance in the last decade. The use of herbal and natural products became mandatory to avoid the side effects of commercially available medications. Aim of the study; the aim was to investigate the anti-cariogenic effect of miswak and grape seed extract (GSE).
详细描述
Patients used Miswak sticks, grape seed extract mouth wash and fluoride mouthwash twice daily for three month. Saliva samples were collected at base line and after one month and three month. Assessment of bacterial count and saliva buffering capacity were performed at base line and after one and three month.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with high caries risk
- •Males or females
- •Medically free patients
- •Patients approving to participate in the study
排除标准
- •Patients who were on antibiotic therapy or corticosteroid therapy for 30 days before the examination
- •Patients had history of professional cleaning in the last 15 days
- •Patients with exposed pulp
- •Evidence of parafunctional habits
- •Patients with developmental dental anomalies
- •Patients undergoing or will start orthodontic treatment
- •Patients with removable prosthesis
- •Periapical Abscess or Fistula
结局指标
主要结局
quantitative measure of the change in salivary streptococcus mutans Count from baseline to one month and three months.
时间窗: Baseline, one month, three months.
the patients used the treatments twice daily for three months. unstimulated saliva samples were collected from the patients at baseline,after one month and after three months. Every time samples were incubated with Mitiis Salivaris with Bacitricin and 20% sucrose for streptococcus mutans count.
次要结局
- quantitative measure of the change in saliva buffering capacity from baseline to one month and three months.(baseline, one month , three months)
研究者
Hala Ahmed Abdel Moneim
Principle Investigator
Al-Azhar University