NCT02784626已完成4 期
The Influence of Intraoperative Sedative on Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: Comparison Between Dexmedetomidine and Propofol
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Visual analogue scale
研究概览
简要总结
In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce postoperative pain in in patients undergoing the total knee arthroplasty.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing total knee arthroplasty
- •Age: 20 - 80 yrs
排除标准
- •ASA classification ≥ 3
- •Patient who do not want sedation during the surgery
- •Patient who wants general anesthesia
- •Cardiovascular disease
- •Liver dysfunction
- •Renal dysfunction
研究组 & 干预措施
Dexmedetomidine
Experimental
Patients who received dexmedetomidine during the operation
干预措施: Dexmedetomidine (Drug)
Propofol
Experimental
Patients who received propofol during the operation
干预措施: Propofol (Drug)
结局指标
主要结局
Visual analogue scale
时间窗: Postoperative 24 hours
Postoperative pain score at postoperative 24 hours
次要结局
- Rescue analgesics(Postoperative 48 hours)
- Visual analogue scale(Postoperative 48 hours)
研究者
Hyo-Seok Na
Associate Professor
Seoul National University Bundang Hospital
研究点 (1)
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