Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma n-3 Polyunsaturated Fatty Acids in Young Compared to Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- Ketone Production
研究概览
简要总结
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging. The precursor long-chain n-3 polyunsaturated fatty acid (PUFA), α-linolenic acid (ALA), is normally mostly β-oxidized and so could potentially be used to stimulate ketogenesis in humans.
Objective: To compare the impact of an ALA-rich supplement on the ketogenic response in young and older healthy adults.
Design: Ten young and ten older adults will consume a flaxseed oil supplement providing 2 g/d of ALA for 4 weeks. Plasma ketones, free fatty acids, triglycerides, glucose and insulin will be measured over 6 h during two metabolic study days, one before and one at the end of the supplementation.
Hypothesis: ALA-rich supplement for 4 weeks will increase ketone production in both groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •aged between 18 and 30 or 65 years and more
排除标准
- •non smoker
- •pregnancy or breastfeeding
- •diabetes or insulin resistance
- •uncontrolled thyroid disease, hepatic or renal disease
- •uncontrolled high blood pressure
- •medical treatment influencing lipid or glucide metabolism
- •ongoing or past severe drug or alcohol abuse
- •dementia or psychiatric difficulties or depression
- •chronic immune condition or inflammation
研究组 & 干预措施
4 week ALA treatment
Participants will receive the alpha-linolenic acid-rich supplement (1000mg 4 times par day) for 4 weeks
干预措施: alpha-linolenic acid-rich supplement (Dietary Supplement)
结局指标
主要结局
Ketone Production
时间窗: After 4 weeks
Total Ketone (acetoacetate + beta-hydroxybutyrate) concentration in plasma in average during the metabolic study day, measured hourly between 1 and 6h after breakfast
次要结局
- Plasma Triglycerides(After 4 weeks)
- Insulin Concentration in Plasma(after 4 weeks)
- Plasma Glucose(After 4 weeks)
- Plasma Free Fatty Acids(4 weeks)