Comparing the Location of the Motor Cortex in Children Using Two Methods: EEG and TMS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Determine the location of the motor cortex by two different means
研究概览
简要总结
Hypothesis: In typically developing children (TDC), use of conventional EEG landmarks to determine the brain area that controls hand function will not differ from TMS-guided determination of individual motor hotspots. In children with hemiparesis, however, those two locations will diverge. The prediction is that TMS will best guide Transcranial Direct Current Stimulation (tDCS) interventions
详细描述
Congenital hemiparesis, mainly due to stroke, affects approximately 25% of children with cerebral palsy. Noninvasive brain stimulation has emerged to influence improvements in hand function specifically in children with congenital hemiparesis due to stroke.
The use of one type of noninvasive brain stimulation, Transcranial Direct Current Stimulation (tDCS), in conjunction with rehabilitation training intervention for a child with hemiparesis proposes a synergistic approach to improving hand function. Application of electrodes over certain targeted areas are placed with the intent to stimulate and influence neuronal activity.
Our preliminary evidence suggests that in children with hemiparesis due to stroke, the area for placement is variable as noted by electroencephalogram (EEG) and Transcranial Magnetic Stimulation (TMS) measurement methods, influencing the site location of optimal stimulation for tDCS.
Due to this variation, the optimal site of stimulation warrants investigation for the optimal placement of tDCS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 8 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Typically Developing Children:
- •Ages 8-17
- •Children with congenital hemiparesis due to hemispheric stroke:
- •Ages 8-17
- •Equal of greater than 10 degrees of active motion at the metacarpophalangeal joint
- •No evidence of seizure activity within the last 2 years.
排除标准
- •Typically Developing Children:
- •neurologic disorders
- •indwelling metal
- •pregnancy
- •history of seizures
- •Children with hemiparesis:
- •Metabolic disorders
- •Disorders of cellular migration and proliferation
- •Expressive aphasia
- •Pregnancy
- •Indwelling metal
- •Botulinum toxin or phenol intramuscular block within the one-month preceding TMS application.
结局指标
主要结局
Determine the location of the motor cortex by two different means
时间窗: 1 year
Determine the location of the motor cortex through two means: 1) The international 10/20 EEG system of measurement and 2) Transcranial Magnetic Stimulation (TMS) testing of cortical excitability in typically developing children and children with hemiparesis.
次要结局
- Measurement of distance in centimeters between the 10/20 EEG C3 or C4 location and the TMS-derived motor hotspot.(1 year)