Eosinophil Markers and Development of Disease in Allergic Rhinitis. A 15-year Follow-up of Patients With Grass Pollen Induced Hayfever.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- Asthma morbidity
研究概览
简要总结
Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.
详细描述
The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed.
If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participant in earlier study (1995)
排除标准
- •Treatment with any kind of corticosteroid within two months will exclude from study of inflammatory parameters
结局指标
主要结局
Asthma morbidity
时间窗: Single measurement - May 2010
Patients are asked whether they have experienced asthmatic symptoms or have been disgnosed with asthma within the latest 15 years
次要结局
- Rhinitis morbidity(Single measurement - May 2010)