A Pilot Study of an Antioxidant Cocktail vs. Placebo in the Treatment of Children and Adolescents With Rett Syndrome
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 35
- 试验地点
- 3
- 主要终点
- Rett Syndrome Natural History Motor Behavior Assessment (MBA)
研究概览
简要总结
This study will examine the potential efficacy and safety of Rett-T for core motor deficits of Rett syndrome, and will explore biological markers of safety and treatment response.
详细描述
There are currently no available medicines shown to be effective for Rett syndrome. Numerous studies implicate mitochondrial dysfunction and oxidative stresses in the pathophysiology of Rett syndrome. Mitochondrial dysfunction has been reported in Rett patients, Rett mouse models and MECP2-deficient cells.
Collaborators have tested a combination of specific antioxidants known to enhance mitochondrial function in a cell and mouse model of Rett syndrome. The formulation normalized mitochondrial membrane potential in MECP2 neurons, and MECP2-deficient mice displayed improved exploratory, locomotor and social behavior compared to MECP2-deficient mice. These results support testing anti-oxidative strategies for benefit in individuals with Rett syndrome.In this study, the formulation has been adjusted and optimized based on current guidelines for human use, with the goal of translating a potential new treatment from the animal model to use in humans. Results of this study could lead to the first approved medication treatment for the disorder.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 2 Years 至 21 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female outpatients 2-21 years of age inclusive.
- •Diagnosis of Rett syndrome.
- •At least partially ambulatory (may need assistive device to take a step).
- •If already receiving stable interventions must meet the following criteria:
- •If already receiving stable concomitant medications or nutraceuticals affecting behaviour, must be on a stable dose during the preceding 1 month prior to Screening (with the exception of fluoxetine, where a period of 6 weeks is needed), and will not electively initiate new or modify ongoing medications for study duration.
- •Have normal laboratory test results at Screening/Baseline. If abnormal, the finding(s) must be deemed clinically insignificant by the Investigator.
- •Ability to complete assessments, fluency in English (parent/legal guardian; participant, if verbal).
- •Ability to obtain assent (if developmentally appropriate), as well as written informed consent from their parent(s)/legal guardian(s).
排除标准
- •Pregnant females; sexually active females on inadequate birth control (extremely unlikely in this population).
- •Have another serious medical condition that, based on Investigator judgment, might interfere with the conduct of the study, confound interpretation of the study results, or endanger their own well-being. Have evidence or history of malignancy or any significant hematological, endocrine, cardiovascular (including any rhythm disorder), respiratory, renal, hepatic, or gastrointestinal disease, not including mild common pediatric diseases in these areas that are stable (e.g. mild asthma, constipation, etc.).
- •Have hypersensitivity to any components of Rett-T.
- •Have one or more of the following: HIV, HBV, HCV, hemophilia (bleeding problems, recent nose and brain injuries), drug abuse, immunity disorder, major depressive episode or psychosis.
- •Unable to tolerate venipuncture procedures for blood sampling.
- •Receiving concomitant medications/nutraceuticals that include any of the components of Rett-T.
- •Actively enrolled in another intervention study.
研究组 & 干预措施
Rett T
Rett T is a powder for oral suspension. Dosage is dependent on weight. For participants weighing <30 kg, a 4 g dose (i.e., one 4 g sachet) is intended to be administered orally once a day after dissolving in approximately 125 mL of water. For participants weighing ≥30 kg, a 8 g dose (i.e., two 4 g sachets) is intended to be administered orally once a day after dissolving in approximately 250 mL of water.
干预措施: Rett-T (Drug)
Placebo
Placebo is a powder for oral suspension. Dosage is dependent on weight. For participants weighing <30 kg, a 4 g dose (i.e., one 4 g sachet) is intended to be administered orally once a day after dissolving in approximately 125 mL of water. For participants weighing ≥30 kg, a 8 g dose (i.e., two 4 g sachets) is intended to be administered orally once a day after dissolving in approximately 250 mL of water.
干预措施: Placebo (Other)
结局指标
主要结局
Rett Syndrome Natural History Motor Behavior Assessment (MBA)
时间窗: 18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim
To examine the effect of Rett-T vs. placebo on measures of motor function. The Rett Syndrome MBA consists of 37 items grouped into three subscales (Behavioral/Social Assessment, Orofacial Respiratory Assessment, and Motor Assessment/Physical Signs). Items are captured on a 0-4 point Likert scale. Total and subscale scores are calculated (subscales are summed for a total score). The scale range for Total score is 0-136; for Behavioral/Social subscale, 0-60; for Orofacial/Respiratory subscale, 0-28; for Motor Assesment/Physical Signs, 0-48. For both total and subscale scores, higher values represent a worse outcome.
次要结局
- Clinical Global Impressions - Improvement Scale - Global (CGI-I)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- Safety Monitoring Uniform Report Form (SMURF)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- Anxiety, Depression, and Mood Scale (ADAMS)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- Rett Syndrome Gross Motor Scale (RSGMS)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- The Top 3 Causes for Concern(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- The Rett Syndrome Behaviour Questionnaire (RSBQ)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)
- Children's Sleep Habits Questionnaire (CSHQ)(18 weeks total: 8 weeks on Rett-T, 8 weeks on placebo, 2 week washout in interim)