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临床试验/NCT07508800
NCT07508800已完成不适用

YONDER Study (Effects of Brief Nature Exposure on Brain Functioning and Stress Reactivity)

National Institutes of Health (NIH)1 个研究点 分布在 1 个国家目标入组 4 人开始时间: 2026年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
4
试验地点
1
主要终点
Brain functioning

研究概览

简要总结

This study is focused on understanding the impact of time spent in nature (relative to an urban control) on stress, neural, and cardiac functioning in people experiencing high levels of stress, depression, and anxiety.

详细描述

Associations between urbanization and mental illness have long been recognized, but the mechanistic pathways underlying this association are not well understood and likely multifactorial. Reduced contact with nature may contribute to the increased psychopathology observed in urban environments.

Theories implicating attention restoration and stress reduction functions via cognitive control and reward brain networks have been proposed to explain how natural environments may decrease stress and promote mental health, particularly in individuals with high-stress loads who are at-risk for developing mental illness. However, most research examining nature's effects on mental health have been observational in design, leaving open questions about nature's effects on neural functioning. Well-controlled studies of brain responses to natural environments will inform stakeholders about potential cognitive and health benefits of nature, as well as guide development of clinical applications like parks prescriptions and nature-based behavioral interventions for individuals who may benefit. This team science grant will enable pilot data collection and a novel collaboration combining faculty expertise in pediatric nature-basedinterventions, clinical neuroscience of reward and motivation, electrophysiological biomarkers of psychiatric vulnerability and integrative healthcare. Further, our team will tap the policy and stewardship expertise of parks system leadership. This project's goal is to conduct a pilot clinical neuroscience study to establish a novel academic-community collaboration and support a larger project proposal to examine neurophysiological mechanisms underlying nature-based clinical interventions to improve mental health in individuals experiencing stress-based symptoms.

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Prospective

入排标准

年龄范围
18 Years 至 25 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Meets cut-off for high level of perceived stress on PSS-10 during screening (>27 total score); Current or past depressive and anxiety disorders, if present on SCID-5 assessment, will be ncluded due to their high prevalence and overlap with perceived stress
  • Normal, or corrected to normal, vision (due to the visual nature of the EEG tasks)
  • If on psychotropic medication, stable regime for > 1 month

排除标准

  • Major medical conditions with CNS sequelae (e.g., seizure disorders, multiple sclerosis, significant, uncontrolled cardiovascular pathology) Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
  • IQ estimate <75 on the Test of Premorbid Functioning
  • Current or past history of severe mental illness (e.g., bipolar schizophrenia spectrum disorder, or current or past history of substance use disorders

结局指标

主要结局

Brain functioning

时间窗: ~1 hour after walking condition

EEG (neural) measures of attention and reward processing ; resting EEG (including frequency-based analyses of canonical frequency bands, e.g., gamma, beta, alpha, delta, theta) and event-related potential measures (reflecting attention, e.g, P300 and reward/affective processing, e.g., reward positivity, late positive potential).

Heart Rate Variability

时间窗: ~ 1 hour after walking manipulaation

This measure reflect the variation in heart beat rate, over time. Specifically we will measure heart rate during the EEG recordings and calculate the RMSSD (Root Mean Square of Successive Differences) of heartbeat R-R intervals.

次要结局

未报告次要终点

研究者

申办方类型
Nih
责任方
Principal Investigator
主要研究者

Susanna Fryer, PhD

Associate Professor

University of California, San Francisco

研究点 (1)

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