Efficacy of 15% Trichloroacetic Acid Peel versus 35% Glycolic Acid Peel in Acanthosis Nigricans – At a Tertiary Care Center in Central Karnataka

Acanthosis nigricans is a common skin condition characterized by hyperpigmented and velvety thickened plaques, most often associated with obesity and insulin resistance. Chemical peels are frequently used to improve pigmentation and texture in such patients. This randomized, prospective, single center clinical trial is designed to compare the efficacy and safety of fifteen percent trichloroacetic acid peel with thirty five percent glycolic acid peel in patients with acanthosis nigricans. Eligible patients will be randomly allocated into two groups to receive either trichloroacetic acid peel or glycolic acid peel at regular intervals. Improvement will be assessed using validated pigmentation scores and patient satisfaction at baseline and at follow up visits. The primary outcome will be reduction in pigmentation, while secondary outcomes include improvement in skin texture and assessment of adverse effects. The findings of this study are expected to provide evidence regarding the relative effectiveness of two commonly used chemical peels in the management of acanthosis nigricans.