Magnetic Resonance Imaging (MRI) Solely For Liver Stereotactic Body Radiation Therapy (SBRT)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- Image quality, as measured by tumor-to-live contrast to noise ratio
研究概览
简要总结
This study is a research and development initiative established to explore the use of magnetic resonance imaging (MRI) as a tool for managing organ motion of the liver in cancer patients planning procedures for stereotactic body radiation therapy (SBRT).
详细描述
There is a potential role to systematically implement MRI to establish appropriate workflow of the implementation for tumor motion management in liver SBRT. Compared to CT, MRI has many significant advantages for radiotherapy planning, including superior tumor and soft-tissue contrast, flexible imaging orientation, freedom from radiation exposure and real-time imaging. MRI solely based liver SBRT will allow for more precise delineation of target volume, less uncertainties in treatment planning, better motion management, and potentially better treatment outcome
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with primary stage I, II, III liver cancer or metastatic tumor in the liver from any cancer site
- •Signed, specific informed consent prior to study entry
- •Women of child bearing potential must have a negative serum pregnancy test
排除标准
- •Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel.
- •Pregnant or breast-feeding women are excluded.
- •Subjects who have difficulty lying flat on their back for extended periods of time
结局指标
主要结局
Image quality, as measured by tumor-to-live contrast to noise ratio
时间窗: During MRI approx 1 hour
Image quality, as measured by image rating
时间窗: During MRI approx 1 hour
Image quality will be measured on a scale of 1 to 5, 1 being the best.
Measure average motion trajectories
时间窗: During MRI approx 1 hour
Image quality, as measured by tumor volume
时间窗: During MRI approx 1 hour
Planning target volume (PTV)
时间窗: During MRI approx 1 hour
PTV is defined as PTV=internal target volume (ITV) + safety margin (M)
次要结局
未报告次要终点