Pilot Study of Coil Arrays in Patients With Advanced Solid Tumor Malignancies
- Conditions
- Neoplams
- Interventions
- Procedure: MRI
- Registration Number
- NCT02390011
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
This is a single center pilot study testing the use of novel coil arrays with MR liver imaging. In part A of the study, up to 30 healthy volunteers will be scanned, with iterative adjustment of coil array geometry and design to optimize imaging characterstics. In Part B of the study, 40 patients with advanced solid tumors and at least one liver metastasis measuring \> 1.5 cm in diameter on standard anatomic scans will undergo MR liver imaging with the newly designed coil array, with the use of gadolinium contrast. Patients with liver tumors will have the option of undergoing a second MR liver scan during the course of subsequent systemic therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 7
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description MRI MRI Day 1
- Primary Outcome Measures
Name Time Method Spatial Resolution Day 1 Adjust the coil array to optimize spatial resolution in healthy volunteers
Scan coverage Day 1 Adjust the coil array to optimize scan coverage of the liver in healthy volunteers
Mean contrast-to-noise ratio Day 1 Detectable using the coil array
- Secondary Outcome Measures
Name Time Method Time-to-peak signal Day 1 Detected by gandolinium contrast in MRI scan within liver metastases
Minimum size of detectable metastatic lesion Day 1 Detected by MRI scan
Degree signal Day 1 Detected by gandolinium contrast in MRI scan within liver metastases
Trial Locations
- Locations (1)
University of California, San Francisco
🇺🇸San Francisco, California, United States