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临床试验/NCT05533931
NCT05533931尚未招募不适用

Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis

Riphah International University2 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2022年9月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
26
试验地点
2
主要终点
oxygen saturation

研究概览

简要总结

The aim of the study is to determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via the incentive spirometer.

详细描述

Chronic Bronchitis (CB) is defined as a chronic cough and sputum production for at least 3 months a year for 2 consecutive years. It is covered under the umbrella term of Chronic Obstructive Pulmonary Disease (COPD). Chronic bronchitis is thought to be caused by overproduction and hypersecretion of mucus by goblet cells. Epithelial cells lining the airway response to toxic, infectious stimuli by releasing inflammatory mediators and e.g. pro-inflammatory cytokines. During an acute exacerbation of chronic bronchitis, the bronchial mucous membrane becomes hyperemic and edematous with diminished bronchial mucociliary function. This, in turn, leads to airflow impediment because of

luminal obstruction to small airways. The airways become clogged by debris and this further increases the irritation. The characteristic cough of bronchitis is caused by the copious secretion of mucus in chronic bronchitis. Pseudostratified epithelium, highlighting the pseudostratified epithelial cells, goblets cells (shown in blue), then underlying connective tissue.(3) To determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via incentive spirometer. There are few studies done over it whereas purpose of this research work is to compare these techniques to get better results.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
45 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • • Diagnosed with chronic bronchitis
  • Clinically stable patients.
  • Both genders.
  • Age 45 to 60 years.
  • Pink puffers included in this study
  • Clients that are involved in research are not allowed for other interventional therapies. They can take their regular medications.
  • Patients diagnosed at least 2 years ago with bronchitis.

排除标准

  • • Presence of any genetic disorders (cystic fibrosis).
  • Recent spinal / chest surgery
  • Cardiac issues
  • Fractures of vertebra caused by osteoporosis.

结局指标

主要结局

oxygen saturation

时间窗: Changes will be assessed at baseline, 3rd week and 6th weeks measured

amount of oxygen traveling through your body with your red blood cells. Changes will be assessed at baseline, 3rd week and 6th weeks measured

Forced expiratory volume in one second

时间窗: Changes will be assessed at baseline, 3rd week and 6th weeks measured

amount of air expired in first one second. Changes will be assessed at baseline, 3rd week and 6th weeks measured

shortness of breath measured through borge scale of dyspnea

时间窗: Changes will be assessed at baseline, 3rd week and 6th weeks measured

shortness of breath. Changes will be assessed at baseline, 3rd week and 6th weeks measured

Forced vital capacity

时间窗: Changes will be assessed at baseline, 3rd week and 6th weeks measured

the total amount of air exhaled during the FEV test. Changes will be assessed at baseline, 3rd week and 6th weeks measured

SGRQ questionnaire

时间窗: Changes will be assessed at baseline, 3rd week and 6th weeks measured

how breathing problems effects quality of life . Changes will be assessed at baseline, 3rd week and 6th weeks measured

FEV1/FVC ratio

时间窗: 6 weeks

the amount of air exhaled in the first second divided by all of the air exhaled during a maximal exhalation.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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