The Effect of Dexmedetomidine on the Remifentanil Concentration for Preventing Cough During Emergence After Propofol Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Number of cough
研究概览
简要总结
Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.
详细描述
Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Care Provider, Investigator)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia
排除标准
- •predicted difficult airway
- •body mass index > 35 kg/m2,
- •recent upper respiratory infection
- •current smoker
- •patients using angiotensin converting enzyme-inhibitors
- •uncontrolled hypertension
研究组 & 干预措施
Dexmedetomidine
Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
干预措施: Dexmedetomidine (Drug)
Dexmedetomidine
Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
干预措施: Remifentanil (Drug)
Remifentanil
Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
干预措施: Remifentanil (Drug)
Remifentanil
Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
干预措施: Normal saline (Drug)
结局指标
主要结局
Number of cough
时间窗: from end of surgery to 5 min after tracheal extubation]
Number of cough or a strong and sudden contraction of the abdomen during periextubation periextubation periods
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Professor
Ajou University School of Medicine