Changes in the Use of Opioids, Antidepressants, and Benzodiazepines in Rheumatoid Arthritis Patients Treated With Biologic Agents

Bristol-Myers Squibb0 个研究点目标入组 1,810 人开始时间: 2009年10月最近更新: 2011年5月17日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 1,810
主要终点: Proportion of RA patients prescribed opioids, benzodiazepines, and antidepressants

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

To compare the proportion of rheumatoid arthritis (RA) patients prescribed opioids, benzodiazepines, and antidepressants before versus after starting each of the following biologics: abatacept, infliximab, etanercept, adalimumab, utilizing an administrative claims database.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Retrospective

入排标准

性别: All
接受健康志愿者: 否

入选标准

•ICD 9 diagnosis RA 714.0
•Documented first biologic prescription ("index" prescription) for abatacept, infliximab, etanercept, or adalimumab
•Continuous therapy (gap between scripts no greater than 150% days supply) for minimum 6 months from index
•Prescription claims data available for 6 months before and 12 months after index biologic prescription
•Continuous eligibility for 6 months before and 12 months after index biologic prescription

排除标准

•Prescription claims for another biologic during the observation period (including rituximab and anakinra)
•Prescriptions not continuous for at least 6 months

结局指标

主要结局

Proportion of RA patients prescribed opioids, benzodiazepines, and antidepressants

时间窗: 7-12 months after index biologic prescription

次要结局

Prevalence of depression and/or anxiety (ICD-9 diagnosis code)(7-12 months after index biologic prescription)

研究者

发起方

Bristol-Myers Squibb

申办方类型

Industry

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