Secretin Levels in Refeeding-induced Polyuria (Cross Section)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in secretin
研究概览
简要总结
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 13 Years 至 24 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •male and female patients
- •age 13-24 years
- •diagnosis of restrictive-type anorexia nervosa
- •hospitalization for nutritional support
- •>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
- •male and female patients
- •age 13-24 years
- •diagnosis of restrictive-type anorexia nervosa
- •hospitalization for nutritional support
- •<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)
排除标准
- •5150 hold
- •Anti-depressant, anti-psychotic, or anticonvulsant medications
- •Previous hospitalization within the past 6 months
- •Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
- •Pregnancy
- •NG or G-tube feeds after day 2 of hospitalization
- •> 10% of nutritional needs from supplemental feeds
研究组 & 干预措施
dumpers
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
non-dumpers
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)
结局指标
主要结局
Change in secretin
时间窗: 1 hour
Change in secretin value from pre- to post- meal
次要结局
- Change in serum bicarbonate(1 hour)
研究者
Elaine L. Rosen, MD
Principal Investigator
University of California, Los Angeles