NCT00108173已完成1 期
Neural Substrates of Treatment for Nicotine Dependence
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- 2-FA PET scan results
研究概览
简要总结
The purpose of the study was to determine how the treatments for cigarette craving work.
Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.
详细描述
PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.
研究设计
- 研究类型
- Interventional
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heavy smoker, more than one pack per day
- •Free of medical conditions or medications that affect brain activity
- •Not pregnant
排除标准
- •Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions
研究组 & 干预措施
Arm 1
Other
干预措施: Zyban (Drug)
结局指标
主要结局
2-FA PET scan results
时间窗: Within the first few weeks of study initiation
Brain activity and activation in response to cigarette-related cues
次要结局
未报告次要终点
研究者
研究点 (1)
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