Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 1
- 主要终点
- time to reverse from light muscle relaxation
研究概览
简要总结
This study aims to find appropriate dose of neostigmine which is possible to reverse rocuronium or cisatracurium till train of four (TOF) 0.9 within 10 minutes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologist Physical status classification 1 or 2 elective surgery under general anesthesia
排除标准
- •BMI >25 or < 20 kg/m2
- •Patients taking intercurrent medication
- •Glutamic Oxalacetate Transaminase or Glutamic Pyruvate Transaminase > 40 IU/L, Cr > 1.4 mg/dl
研究组 & 干预措施
Rocuronium-placebo
At anesthetic induction, rocuronium 0.6 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four (TOF) using nerve stimulator. When TOF ratio recover to 0.5, normal saline 5 ml will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Rocuronium-neostigmine 10 ㎍
At anesthetic induction, rocuronium 0.6 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 10 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0.
干预措施: Injection of neostigmine (Drug)
Rocuronium-neostigmine 20 ㎍
At anesthetic induction, rocuronium 0.6 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 20 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Rocuronium-neostigmine 40 ㎍
At anesthetic induction, rocuronium 0.6 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 40 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Cisatracurium-placebo
At anesthetic induction, cisatracurium 0.15 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, normal saline 5 ml will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Cisatracurium-neostigmine 10 ㎍
At anesthetic induction, cisatracurium 0.15 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 10 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Cisatracurium-neostigmine 20 ㎍
At anesthetic induction, cisatracurium 0.15 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 20 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
Cisatracurium-neostigmine 40 ㎍
At anesthetic induction, cisatracurium 0.15 mg/kg will be injected for muscle relaxation.
During surgical procedure, we will monitor train of four(TOF)using nerve stimulator. When TOF ratio recover to 0.5, neostigmine 40 ㎍/kg will be injected. And we will measure time to take from TOF ratio 0.5 to 1.0
干预措施: Injection of neostigmine (Drug)
结局指标
主要结局
time to reverse from light muscle relaxation
时间窗: time from TOF 0.5 to TOF 1.0 after injection of different doses of neostigmine
Primary outcome of this study is how long it takes time to reverse from TOF ratio 0.5 to 1.0 after injection of different doses of neostigmine at the TOF 0.5
次要结局
- time to reverse from TOF ratio 0.5 to 0.9(time from TOF 0.5 to TOF 0.9 after injection of different doses of neostigmine)