Effects of Asparagus Capsule Consumption on Blood Sugar and Lipids and Oxidative Stress in Overweight and Obese Participants
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Level of body fat
研究概览
简要总结
Participants were 44 overweight and obese persons, male and female, age 18-59 years. Participants were divided into 2 groups consisting of 23 asparagus capsules and 21 placebo capsules groups. They received health screenings including history taking, mental health questionnaire, and vital signs, height and body weight, body composition, fat distribution measurements and oral glucose tolerance test. Then, a venipuncture was conducted to determine blood glucose, insulin, lipids malondialdehyde and protein carbonyl levels.
详细描述
The study design was cross-sectional. Participants were 44 overweight and obese persons, male and female, age 18-59 years. Participants were divided into 2 groups consisting of 23 asparagus capsules and 21 placebo capsules groups. They received health screenings including history taking, mental health questionnaire, and vital signs, height and body weight, body composition, fat distribution measurements and oral glucose tolerance test. Then, a venipuncture was conducted to determine blood glucose, insulin, lipids malondialdehyde and protein carbonyl levels. Analysis of covariance was used to analyze parameters between groups and paired t-test was used to analyze parameters intra-group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Man or woman, aged between 18 to 59 years
- •Body mass index more than 23 (Asian criteria)
- •No history of hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer
- •No regular intake of dietary supplements, i.e., vitamins, antioxidants
- •No regular smokers or alcohol drinkers (>2 times per week)
- •Not sportman or regular exerciser (>2 times per week or >150 min per week)
- •No food allergy, especially shoot
排除标准
- •Current signs or symptoms of infection, i.e., fever, hyperpnea, dyspnea, and palpitations.
结局指标
主要结局
Level of body fat
时间窗: Day 0 and end of 12 weeks
Level of body fat was measured in percentage unit
Level of fat mass
时间窗: Day 0 and end of 12 weeks
Level of fat mass was measured in kilogram unit
Level of fat distribution
时间窗: Day 0 and end of 12 weeks
Level of fat distribution was measured by ratio of waist (centimeter) to hip (centimeter)
Concentration of blood glucose
时间窗: Day 0 and end of 12 weeks
Concentration of blood glucose was measured in serum in mmol/L unit
Concentration of blood insulin
时间窗: Day 0 and end of 12 weeks
Concentration of blood insulin was measured in serum in uU/mL (microunit/milliliter) unit
Concentration of blood malondialdehyde
时间窗: Day 0 and end of 12 weeks
Concentration of blood malondialdehyde was measured in plasma in uM (micromolar) unit
Concentrations of blood lipids
时间窗: Day 0 and end of 12 weeks
Concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured in serum in mg/dL unit
Concentration of blood protein carbonyl
时间窗: Day 0 and end of 12 weeks
Concentration of blood protein carbonyl was measured in plasma in nmol/mg protein unit
次要结局
- Concentrations of blood glucose from oral glucose tolerance test(At 0 minute before glucose consumption and at 30, 60, 90, 120 minutes after glucose consumption)
研究者
Piyapong Prasertsri
Associate Professor Dr.
Burapha University